New nanotech method loads stem cells with extra mitochondria to recharge dying cells

Scientists at Texas A&M University have developed a novel nanotechnology-based method to enhance stem cells by loading them with extra mitochondria, the cell’s energy-producing structures, to rejuvenate weakened or dying cells. Using microscopic molybdenum disulfide "nanoflowers," the researchers stimulated stem cells to produce roughly twice their normal mitochondrial content. These mitochondria-enriched stem cells then transferred the surplus mitochondria to damaged cells, restoring their energy output and improving their survival under stress conditions such as chemotherapy-like insults. This approach effectively "recharges" failing cells without relying on drugs or genetic modifications. The technique shows promise for treating age-related and degenerative diseases linked to mitochondrial decline, including heart disease and neurodegenerative disorders. Unlike existing small-molecule drugs that rapidly clear from cells, the nanoflowers remain inside stem cells longer, potentially allowing for less frequent dosing. The method’s flexibility allows targeted delivery of enhanced stem cells to various tissues, such as the heart or muscles, broad