Scientists create gel that restores lost enamel within two weeks

Scientists at the University of Nottingham have developed a novel protein-based gel that can regenerate lost tooth enamel within two weeks, potentially transforming dental restoration and preventive care. Unlike traditional fluoride treatments that only slow enamel decay, this bioinspired gel mimics the natural proteins responsible for enamel growth during infancy. When applied, it forms a durable layer that penetrates microscopic cracks and promotes the organized growth of new enamel minerals through epitaxial mineralization, effectively restoring both the structure and function of natural enamel. This fluoride-free gel can also grow enamel-like layers on exposed dentine, addressing tooth sensitivity and improving dental restoration bonding. The regenerated enamel has been tested under real-life conditions such as brushing, chewing, and acidic exposure, demonstrating mechanical properties comparable to healthy enamel. Given enamel degradation affects nearly half the global population and contributes to cavities and systemic health issues, this innovation offers a significant advancement over current treatments that only manage symptoms without restoring enamel. The research team emphasizes the gel’s safety, ease of application, and scalability