What is Genesis Mission, and how it speeds up US scientific research

The Genesis Mission is a comprehensive U.S. government initiative aimed at revolutionizing scientific research by integrating artificial intelligence (AI) as the central driver of discovery. Announced via a White House Executive Order, the mission seeks to unify the nation’s top supercomputers, extensive scientific datasets, and advanced AI systems into a single, secure platform called the American Science and Security Platform. This platform will enable AI agents to run simulations, analyze data, generate hypotheses, and even control robotic laboratories, creating an end-to-end architecture for accelerated scientific innovation across fields such as energy, biotechnology, materials science, and national security. At the heart of the mission is the Department of Energy’s (DOE) responsibility to develop the necessary computing infrastructure, leveraging exascale supercomputers like Frontier and Aurora to perform massive calculations and train scientific foundation models. The initiative builds on prior AI-driven breakthroughs—such as AlphaFold’s protein folding solution and AI-discovered antibiotics—demonstrating AI’s ability to process vast data,