Articles tagged with "biomedical-engineering"
New 3D-printed liver could help treat organ failure without transplant
A Carnegie Mellon University-led team is developing a functional 3D bioprinted liver through the Liver Immunocompetent Volumetric Engineering (LIVE) project, aimed at addressing the critical shortage of donor organs for liver transplants. Funded with $28.5 million from the US Advanced Research Projects Agency for Health (ARPA-H), the project focuses on creating a temporary liver that can support patients suffering from acute liver failure for two to four weeks. This temporary organ would provide a crucial window for the patient’s own liver to regenerate, potentially eliminating the need for a full transplant and preserving scarce donor livers for others. The LIVE team employs a proprietary FRESH 3D bioprinting technique to fabricate soft biological materials like collagen and human stem cells into complex liver structures. To overcome immune rejection, they use genetically engineered hypoimmune "universal donor" cells that evade the recipient’s immune system, removing the need for toxic immunosuppressive drugs. Beyond the liver, the researchers
materials3D-printingbioprintingregenerative-medicinebiomedical-engineeringorgan-transplantbioengineeringChina makes womb on a chip to shed light on first days of pregnancy
Chinese scientists have developed a "womb on a chip," a three-dimensional microfluidic model that replicates the human uterine lining (endometrium) to study embryo implantation, a critical and previously hard-to-study stage of early pregnancy. This chip-based system uses human endometrial cells embedded in gel-like layers to form tissue that closely mimics the natural uterine environment. The model supports the full implantation process, including embryo attachment and invasion, by introducing either real human blastocysts or lab-made blastoids derived from stem cells. This advancement overcomes ethical and practical limitations of studying early human pregnancy and offers a more accurate and detailed platform than previous two-dimensional cultures. The researchers demonstrated that embryos implanted successfully within the chip, recapitulating key stages such as apposition, attachment, and invasion, as well as early post-implantation development. Importantly, when using cells from women with recurrent implantation failure (repeated IVF failures), the embryos showed significantly reduced implantation success, reflecting
microfluidic-chiporgan-on-a-chipbiomedical-engineeringhuman-embryo-implantationIVF-researchtissue-engineeringlab-on-a-chipFast MRI imaging lets doctors steer magnetic microrobots in real time
Researchers at Huazhong University of Science and Technology in China have developed an innovative magnetic resonance imaging (MRI) technique that enables real-time, artifact-free navigation of magnetic microrobots inside the body. Their multi-frequency dual-echo (MFDE) MRI sequence dramatically reduces the repetition time from about 1,000 milliseconds to just 30 milliseconds, allowing near real-time imaging with high spatial accuracy. This advancement addresses previous challenges in MRI-driven robotic control, such as slow imaging speeds, tracking inaccuracies, and interference between imaging gradients and robot motion. The MFDE method uses dual echoes generated by two adjacent 180-degree radio-frequency pulses and alternates positive and negative offset frequency excitations to maintain image quality despite rapid scanning. The system was validated through experiments including guiding a magnetic microrobot through a complex 3D maze, navigating phantom endovascular models mimicking tortuous vessels, and in vivo navigation within a rat’s large intestine. These demonstrations highlight the potential of this technology for minimally invasive medical
roboticsmagnetic-microrobotsMRI-imagingmedical-roboticsreal-time-navigationminimally-invasive-surgerybiomedical-engineeringNew single-donor, breathing lung chip mimics the unseen stages of TB
Researchers at the Francis Crick Institute and Swiss company AlveoliX have developed the first breathing “lung-on-chip” model created entirely from a single individual’s cells. Using induced pluripotent stem cells (iPSCs), the chip replicates a genetically identical miniature lung ecosystem that mimics the mechanical expansion of human breathing through rhythmic three-dimensional stretching. This innovation overcomes previous limitations where lung models used mixed-cell sources, enabling precise observation of how a specific person’s lung cells and immune system respond to infections like Tuberculosis (TB). The chip incorporates donor-matched immune cells (macrophages) and TB bacteria to simulate the early, unseen stages of TB infection within a consistent genetic environment. Researchers observed the formation of necrotic cores—clusters of dead immune cells—days before lung barrier collapse, providing new insights into TB’s slow progression that is difficult to study in humans or animal models. This personalized lung-on-chip technology offers a promising alternative to animal testing and could be expanded to study
materialsorgan-on-chiplung-on-chipbiomedical-engineeringinduced-pluripotent-stem-cellspersonalized-medicinedisease-modelingPhotos: New robotic vest lets dogs with leg injuries walk using their own muscles
The Repawse exoskeleton, developed by Zhou Leijing and her team in Hangzhou, China, is an innovative device designed to help dogs with hind leg injuries walk naturally using their own muscle signals. Unlike traditional mobility aids that passively support movement, Repawse employs surface electromyographic (sEMG) sensors on a healthy front leg to detect muscle activity, which a control system then uses to predict and coordinate the motion of the injured hind leg. This synchronization allows dogs to lead their own movement, resulting in a more natural and stress-free walking experience without relying on forced or artificial motion. Inspired by Zhou’s personal experience caring for an injured dog, Repawse adapts human exoskeleton rehabilitation technology specifically for canine anatomy and movement patterns. The lightweight, responsive, and safe device fills a critical gap in pet rehabilitation by enabling dogs to regain coordinated walking rather than simply supporting their bodies with passive prosthetics or carts. Recognized with the Silver A’ Pet Care Design Award in
roboticsexoskeletonpet-rehabilitationassistive-technologywearable-roboticsanimal-healthbiomedical-engineeringNew US-made brain–computer interface runs on one tiny silicon chip
Researchers from Columbia University, New York-Presbyterian Hospital, Stanford University, and the University of Pennsylvania have developed a new brain-computer interface (BCI) platform called the Biological Interface System to Cortex (BISC). This system features an ultra-thin, single-chip implant made from a 50-micrometer-thin CMOS integrated circuit that rests flexibly on the cortical surface. Unlike conventional BCIs that rely on bulky assemblies of multiple components, BISC integrates 65,536 electrodes, 1,024 recording channels, and 16,384 stimulation channels on a single chip with all signal processing, wireless communication, and power management included. The implant wirelessly transmits neural data at speeds up to 100 Mbps—over 100 times faster than comparable devices—via a wearable relay station that also provides power and Wi-Fi connectivity, enabling seamless brain-to-external device communication. The BISC platform is designed to support a wide range of applications, including epilepsy management and restoring motor,
IoTbrain-computer-interfacewireless-communicationsilicon-chipneural-databiomedical-engineeringneuroprostheticsScientists are turning human brain cells into functional computers
Scientists are pioneering the development of biocomputers made from living human brain cells, specifically lab-grown neurons formed into organoids connected to electrodes to perform computational tasks. These biocomputers currently handle simple functions, such as playing the game Pong or recognizing Braille letters, and operate with significantly greater energy efficiency than traditional silicon-based computers. The technology builds on decades of neuroscience research, with a major leap occurring in 2013 when brain organoids—3D structures grown from stem cells—became widely used for studying brain function and drug testing. Despite promising advances, biocomputing remains in its infancy, with ongoing efforts focused on growing human neurons into functional systems comparable to biological transistors. The field faces ethical challenges, as current guidelines treat organoids merely as biomedical tools, even though some researchers have raised concerns about the implications of terms like “embodied sentience” and “organoid intelligence.” Experts generally agree that current organoids are not conscious, but there is a pressing need
energybiocomputingbrain-organoidsbio-hybrid-computingenergy-efficiencybiomedical-engineeringorganoid-intelligenceStudents create closed-loop insulin pump software for diabetes care
A team of five biomedical engineering students from Texas A&M University, sponsored by Medtronic MiniMed, developed a prototype closed-loop algorithm for an implantable insulin pump system aimed at improving diabetes care for patients with Type 1 diabetes. Unlike many existing insulin pumps that require manual adjustments, this system automates insulin delivery by continuously communicating with a glucose monitor. The algorithm adjusts insulin doses based on real-time blood sugar levels, reducing the need for patient input and potentially easing the mental burden of disease management. Team member Jacob Kimbrough, who has Type 1 diabetes himself, contributed personal insight to the project, emphasizing the importance of automation in daily care. This innovation represents a step toward more advanced, artificial pancreas-like systems that operate inside the body rather than as external devices. Medtronic MiniMed views the students’ work as promising early progress and plans to further develop and refine the algorithm. The collaboration also provided valuable real-world engineering experience for the students and aligns with ongoing efforts to create safer,
IoThealthcare-technologyinsulin-pumpclosed-loop-systemdiabetes-managementbiomedical-engineeringmedical-devicesNew nanotech method loads stem cells with extra mitochondria to recharge dying cells
Scientists at Texas A&M University have developed a novel nanotechnology-based method to enhance stem cells by loading them with extra mitochondria, the cell’s energy-producing structures, to rejuvenate weakened or dying cells. Using microscopic molybdenum disulfide "nanoflowers," the researchers stimulated stem cells to produce roughly twice their normal mitochondrial content. These mitochondria-enriched stem cells then transferred the surplus mitochondria to damaged cells, restoring their energy output and improving their survival under stress conditions such as chemotherapy-like insults. This approach effectively "recharges" failing cells without relying on drugs or genetic modifications. The technique shows promise for treating age-related and degenerative diseases linked to mitochondrial decline, including heart disease and neurodegenerative disorders. Unlike existing small-molecule drugs that rapidly clear from cells, the nanoflowers remain inside stem cells longer, potentially allowing for less frequent dosing. The method’s flexibility allows targeted delivery of enhanced stem cells to various tissues, such as the heart or muscles, broad
nanotechnologystem-cellsmitochondriaenergy-restorationbiomedical-engineeringnanomaterialscellular-therapyMicroneedle heart patch aims to improve post-attack recovery
Researchers at Texas A&M University have developed a biodegradable microneedle patch designed to improve recovery of heart muscle damaged by heart attacks. The patch delivers interleukin-4 (IL-4) directly into the injured heart tissue through tiny needles that penetrate the heart’s outer layer, enabling targeted drug delivery that reduces scarring and inflammation without the systemic side effects seen in previous methods. IL-4 shifts macrophages—immune cells central to the healing process—from promoting inflammation to supporting tissue repair, thereby helping the heart muscle recover more effectively. Early experiments demonstrated that the patch not only decreased inflammatory signals and scar tissue formation but also enhanced communication between heart muscle cells and endothelial cells lining blood vessels, which may support long-term heart function. Additionally, the patch increased activity in the NPR1 pathway, known to promote blood vessel health and reduce harmful inflammation. While the current version requires open-chest surgery, the researchers aim to refine the design for less invasive delivery, potentially via catheter. The study, published in
materialsbiomedical-engineeringdrug-deliverymicroneedle-patchheart-repairtissue-engineeringbiodegradable-materialsA New Light-Based Cancer Treatment Kills Tumor Cells and Spares Healthy Ones
Researchers from the University of Texas at Austin and the University of Porto have developed tin oxide (SnOx) nanoflakes that efficiently convert near-infrared (NIR) light into heat to selectively destroy cancer cells while sparing healthy tissue. These nanoflakes, less than 20 nanometers thick, accumulate in tumor tissues and, when exposed to NIR light at 810 nanometers, generate localized heat sufficient to kill cancer cells without damaging surrounding healthy cells. This approach represents an advancement in photothermal therapy, a noninvasive cancer treatment that uses light-activated materials to heat and eliminate tumors. The team designed an affordable and safe experimental setup using NIR-LEDs instead of traditional lasers, providing stable, homogeneous illumination with minimal risk of overheating. This system, costing about $530 and capable of treating multiple samples simultaneously, offers a practical tool for biomedical research. In laboratory tests, the SnOx nanoflake treatment killed up to 92% of skin cancer cells and
materialsnanomaterialsphotothermal-therapycancer-treatmenttin-oxide-nanoflakesnear-infrared-lightbiomedical-engineeringAI-powered muscles made from lifelike materials perform safe actions
Researchers at the Georgia Institute of Technology have developed AI-powered artificial muscles made from lifelike, hierarchically structured flexible fibers that mimic human muscle and tendon. These soft, responsive muscles are paired with intelligent control systems that enable them to sense, adapt, and "remember" previous movements, allowing for real-time adjustment of force and flexibility. Unlike traditional rigid robots, these artificial muscles aim to produce natural, smooth, and safe motions, making them particularly suitable for applications such as stroke recovery or prosthetics, where rebuilding strength and confidence is crucial. The research, published in Materials Horizon, highlights advancements in functional materials, structural design, and manufacturing techniques that enable these muscles to execute pre-programmed movements and respond dynamically to environmental changes through sensory feedback. The team emphasizes the importance of adaptability and biocompatibility, ensuring the materials can integrate safely with the human body without triggering immune responses. Challenges remain in scalability and dynamic reprogramming, but the work represents a significant step toward prosthetics and assistive devices
robotartificial-musclesflexible-materialsAI-powered-roboticssmart-materialsadaptive-roboticsbiomedical-engineeringA flexible lens controlled by light-activated artificial muscles promises to let soft machines see - Robohub
Researchers at Georgia Institute of Technology have developed a flexible, adaptive lens inspired by the human eye, designed to provide vision capabilities for soft robots and biomedical devices. This photo-responsive hydrogel soft lens (PHySL) uses light-activated, water-based polymer “muscles” to change its shape and focal length without mechanical parts or electronics. Unlike traditional camera lenses that rely on bulky, rigid components, the PHySL mimics the eye’s ciliary muscles by contracting in response to light, enabling precise, contactless control of focus and intensity. Its soft, compliant structure enhances durability and safety, particularly for applications involving close contact with the human body. This innovation addresses challenges in soft robotics and biomedical tools, where flexible, low-power, and autonomous systems are crucial. Soft robots, made from compliant materials, benefit from adaptable vision systems that can withstand deformation and operate without complex electronics. The PHySL’s electronics-free design contrasts with existing soft lens technologies that often require liquid-filled actuators or electronic
robotsoft-roboticsartificial-muscleshydrogel-materialsadaptive-lensbiomedical-engineeringsoft-materialsScientists find hidden geometric code shaping how human DNA works
A new study from Northwestern University, led by biomedical engineer Vadim Backman, reveals a previously unknown "geometric code" embedded in the three-dimensional structure of human DNA. Unlike the traditional genetic code based on the sequence of chemical bases (A, C, T, G), this geometric code arises from the spatial folding and nanoscale organization of DNA within cells. These physical configurations form "packing domains" that act as memory nodes, enabling cells to compute, store, and regulate genetic activity dynamically. This discovery suggests that the genome functions not just as a static script but as a living computational system, with its shape playing a critical role in gene behavior and cellular memory. The research implies that evolution may have advanced complexity not solely through new genes but by optimizing the geometric arrangement of existing genetic material, enhancing information storage and retrieval. This geometric language could bridge biology and computation, paralleling principles seen in artificial intelligence. Moreover, the fidelity of this geometric code appears to degrade with age, potentially contributing to diseases
materialsDNA-nanotechnologybiomedical-engineeringgenetic-codecellular-memorygenome-structurebiotechnologyThe real engineering problem behind brain–computer interfaces
The article "The real engineering problem behind brain–computer interfaces" highlights that the primary challenge in developing neuroprosthetics is not simply creating brain implants but ensuring their long-term durability and reliability inside the brain. While capturing the brain's faint electrical signals is difficult due to their low amplitude and noise interference, the most significant engineering hurdle lies in designing electrodes and packaging that can survive the brain’s hostile environment without provoking immune rejection or signal degradation. Implantable electrodes must penetrate or rest on the cortex for extended periods, but the body often reacts by forming scar tissue or inflammation, which degrades signal quality over time. To address these issues, companies are focusing on selecting materials and sealing methods that can last for decades. For example, Paradromics uses platinum–iridium electrodes and aerospace-grade hermetic enclosures to protect implants, contrasting with softer polymer-based probes like Neuralink’s threads, which may only last under two years. Researchers also emphasize the need for ultra-thin or flexible electrodes to minimize tissue damage
robotmaterialsenergyneuroprostheticsbrain-computer-interfacesimplantable-electrodesbiomedical-engineeringMagnetic microcatheter rides blood flow for deeper vessel access
Researchers at EPFL have developed MagFlow, an ultraminiaturized magnetic microcatheter that leverages blood flow and magnetism to navigate the body’s narrowest arteries—some thinner than a human hair. Unlike traditional guidewire-based catheters, which are slow, difficult to steer, and risk damaging vessel walls, MagFlow uses the bloodstream’s kinetic energy to move forward, minimizing contact with vessel walls. This innovation could significantly expand treatment options for conditions such as stroke, arteriovenous malformations, and pediatric eye cancers by reaching vessels previously inaccessible to conventional catheters. The device consists of two bonded polymer sheets forming a flexible body capable of inflating to deliver various liquids, including contrast agents and embolizing materials. Steering is achieved through a robotic control system called OmniMag, which uses a magnetic field generator guided by a doctor’s hand movements to precisely orient MagFlow’s magnetic tip. Successful animal trials demonstrated safe navigation through complex, narrow arteries in pigs, delivering therapeutic agents effectively.
robotmedical-roboticsmicrocathetermagnetic-navigationminimally-invasive-surgerybiomedical-engineeringmagnetic-control-systemMiraqules will showcase its blood clotting technology at TechCrunch Disrupt 2025
Bengaluru-based startup Miraqules has developed an innovative nanotechnology powder that mimics blood clotting proteins, enabling rapid blood absorption and clotting within one to two minutes at room temperature. The technology emerged accidentally during biomedical research and was refined into a product that provides instant feedback by stopping bleeding quickly when applied. Miraqules has secured 11 patents across seven countries, including India, the U.S., and Israel, and is currently piloting its product in an Indian trauma care center. The company anticipates regulatory approval in India soon and expects U.S. FDA clearance by 2026. Despite raising less than $700,000 primarily through grants, Miraqules has attracted interest from multiple hospital chains in India and the Israeli Defense Forces. The founders engaged early with the U.S. FDA through pre-submission feedback to streamline the approval process. Miraqules will showcase its blood clotting technology as a Top 20 finalist at TechCrunch Disrupt 2025, held October
materialsnanotechnologybiomaterialsblood-clottingmedical-technologybiomedical-engineeringpatentsUS scientists create microscopic 'flower robots' for drug delivery
Scientists at the University of North Carolina have developed microscopic "DNA flower" robots—soft, flower-shaped structures made from hybrid crystals combining DNA with inorganic materials like gold or graphene oxide. These nanoscale robots can rapidly fold and unfold in response to environmental stimuli such as changes in acidity, temperature, or chemical signals. This reversible motion, guided by the programmable nature of DNA assembly, allows the DNA flowers to perform adaptive tasks including molecule delivery, triggering chemical reactions, and interacting with biological tissues. The research aims to mimic natural adaptive behaviors seen in living organisms, such as coral movements and blossoming petals, by creating artificial systems capable of sensing and reacting dynamically at a microscopic scale. Potential applications include targeted drug delivery inside the body, minimally invasive biopsies, clearing blood clots, and environmental cleanup by responding to pollutants. Although still in early stages, these DNA flower robots represent a promising new class of soft nanorobots that combine biological programming with stable inorganic components to repeatedly transform shape without structural loss, opening
robotnanorobotsdrug-deliveryDNA-nanotechnologysoft-roboticssmart-materialsbiomedical-engineering3D human colon model may replace animal testing in cancer labs
Researchers at the University of California, Irvine have developed a bioelectronic-integrated three-dimensional human colon model (3D-IVM-HC) that replicates key anatomical and cellular features of the human colon, including its curvature, layered structure, and cryptlike folds. This miniature model, measuring 5 by 10 millimeters, is constructed from human-compatible materials such as gelatin methacrylate and alginate, and is lined with human colon cells and fibroblasts to mimic the mucosal environment. The model supports more realistic cell behavior and interactions, resulting in a fourfold increase in cell density compared to traditional 2D cultures, enhancing physiological relevance and barrier function. The 3D-IVM-HC model addresses significant limitations of animal testing in colorectal cancer research by offering a more ethical, cost-effective, and scalable alternative that eliminates interspecies variability. Testing with the chemotherapy drug 5-fluorouracil demonstrated that cancer cells in the model exhibited drug resistance levels closer to clinical
bioelectronics3D-human-colon-modelcancer-researchbiomedical-engineeringdrug-testing-alternativesmaterials-scienceprecision-medicineSmart menstrual cup tracks infections, redefines period care
Researchers at McMaster University have developed an innovative menstrual cup that enhances period care by combining hygiene, sustainability, and health monitoring. Central to this advancement is a flushable seaweed-based tablet that can be inserted into the existing Bfree Cup, a lubricant-infused silicone cup that naturally repels viruses and bacteria. The tablet improves usability by absorbing menstrual blood to reduce spills, addressing a common challenge with menstrual cups. This combination offers a more hygienic, eco-friendly, and user-friendly alternative to traditional menstrual products, with the potential to reduce period poverty, especially in low- and middle-income countries where access to safe menstrual care is limited. Beyond improving convenience and sustainability, the researchers envision future versions of the cup equipped with biosensors capable of detecting early signs of infections and blood-borne illnesses, effectively transforming the cup into a wearable health monitoring device. This proactive approach could enable earlier diagnosis of conditions such as endometriosis and urinary tract infections, representing a significant shift from reactive to preventive women’s health care
IoTwearable-technologymenstrual-healthbiomedical-engineeringsustainable-materialshealth-monitoringdiagnosticsKorean researchers create bone-healing gun, offers faster treatment
Korean researchers at Sungkyunkwan University have developed a handheld “bone-healing gun,” a 3D-printing device that extrudes biodegradable polymer scaffolds directly onto fractured bones to accelerate healing. Unlike traditional metal grafts and titanium implants, which are costly and difficult to customize, this device uses a biocompatible filament made from a blend of polycaprolactone and hydroxyapatite. This material melts at a safe 60 °C, allowing it to bond securely to bone tissue without damaging surrounding areas, while providing strength comparable to natural bone and gradually degrading as new bone grows. Early animal trials on rabbits with femur fractures showed that the bone-healing gun significantly sped up recovery compared to standard bone cement. However, the slow degradation rate of the scaffold material limited full fracture restoration, indicating the need for further improvements before human trials. The researchers aim to enhance the material’s biodegradation speed and incorporate antibiotics to release infection-fighting drugs during healing. Additional challenges include ensuring
materialsbiodegradable-polymers3D-printingbone-healingbiomedical-engineeringmedical-devicespolymer-scaffoldsScientists build modular biobots from human lung cells and cilia
Researchers at Carnegie Mellon University have developed a novel class of living, modular biobots called AggreBots, engineered from human lung cells and powered by cilia—microscopic hair-like structures that enable movement by propelling fluids. Unlike traditional biobots that rely on muscle fibers for motion, AggreBots utilize cilia-based propulsion, offering a new approach to controlling microscale robot motility. The team’s innovative method involves assembling tissue spheroids derived from lung stem cells, including genetically modified spheroids with immotile cilia, to precisely control the location and function of cilia on the biobot surface. This modular design allows customizable movement patterns, akin to selectively removing oars from a rowboat to influence its direction. The biobots’ fully biological composition makes them biodegradable and biocompatible, enhancing their potential for medical applications such as targeted therapeutic delivery within the body. Because AggreBots can be created from a patient’s own cells, they may avoid immune rejection and enable
robotbiobotsbiomedical-engineeringciliamodular-designbiohybrid-robotsmedical-robotics3D printing creates human tissue with stretch and blood-like fluids
Researchers at the University of Minnesota Twin Cities have developed an advanced 3D printing technique that produces human tissue models with realistic mechanical properties and blood-like fluids, significantly improving the fidelity of surgical training tools. By controlling microscopic patterns within the printed material, the team achieved tissues that mimic the strength and stretchiness of real organs. Additionally, they incorporated sealed microcapsules containing blood-like liquids to enhance the models’ realism without compromising the printing process. Surgeons who tested these models rated them higher than conventional replicas in tactile feedback and cutting response, suggesting that such improvements could lead to safer and more effective surgical practice. The research team, including experts from mechanical and biomedical engineering and collaborators from the University of Washington, also developed a mathematical formula to predict tissue behavior under stress. While scaling the technology for widespread use will take time, the method shows strong potential for specialized, low-volume training scenarios. Future research aims to replicate various organ shapes and functions, develop bionic organs, and integrate materials responsive to advanced surgical tools
3D-printingbiomaterialssurgical-trainingtissue-engineeringmedical-devicessynthetic-organsbiomedical-engineering3D printable bio-glass scaffold shows promise as bone replacement
Researchers in China have developed a novel 3D printable bio-active glass scaffold that shows promise as a bone replacement material. Unlike traditional glass, which is brittle and difficult to shape safely for medical use, this new bio-glass combines silica particles with calcium and phosphate ions to form a printable gel. This gel can be hardened at a relatively low temperature (1,300°F), avoiding the toxic plasticizers and extreme heat (above 2,000°F) typically required in glass 3D printing. In animal tests involving rabbit skull repair, the bio-glass scaffold supported sustained bone cell growth over eight weeks, outperforming plain silica glass and nearly matching a leading commercial dental bone substitute in durability. The key innovation lies in the “green” inorganic 3D printing strategy, which uses self-healing colloidal gels made from silica-based nanospheres that attract each other electrostatically. This method eliminates the need for organic additives, reduces costs, preserves bioactivity, and enhances printability and shape
materials3D-printingbio-glassbone-replacementbiomedical-engineeringnanomaterialsadditive-manufacturingSticky hydrogel slows drug release 20x, extends treatment span
Researchers at Rice University have developed a novel peptide hydrogel platform called SABER (self-assembling boronate ester release) that significantly slows drug release, extending treatment duration by up to 20 times. SABER works by forming a three-dimensional net that temporarily traps drug molecules, allowing for gradual release. This system is versatile, effective for a range of drugs from small molecules to large biologics like insulin and antibodies. In mouse studies, a single SABER injection of a tuberculosis drug outperformed nearly daily oral doses over two weeks, and insulin delivered via SABER controlled blood sugar for six days compared to the usual four-hour effect of conventional insulin. The hydrogel is biocompatible, dissolving safely after injection without toxic byproducts. The SABER platform was developed through interdisciplinary collaboration, combining chemistry and biomedical engineering expertise. The concept originated from dynamic covalent bonds used in glucose sensors, adapted to create a "sticky" hydrogel that controls drug release timing and location. The research team is
materialshydrogeldrug-deliverypeptide-hydrogelbiomedical-engineeringcontrolled-releaseSABER-platformScientists turn sperm into microrobots to advance infertility care
Researchers at the University of Twente’s TechMed Centre have developed a novel technique to transform human sperm cells into magnetically controlled microrobots that can be tracked and steered inside a life-sized anatomical model using X-ray imaging. By coating sperm with magnetic nanoparticles, the team overcame the challenge of sperm’s invisibility under conventional imaging, enabling real-time visualization and precise navigation within the body. This breakthrough merges the natural mobility and flexibility of sperm with advanced robotics, opening new possibilities for targeted drug delivery and diagnostic applications in hard-to-reach reproductive areas. The technology holds promise for revolutionizing treatments of uterine conditions such as cancer, endometriosis, and fibroids by enabling minimally invasive, site-specific drug delivery. Additionally, tracking sperm movement in real time could enhance understanding of fertilization processes, unexplained infertility, and improve assisted reproductive techniques like IVF. Safety tests indicate that the sperm-nanoparticle clusters are biocompatible, showing no significant toxicity to human uterine cells after
robotmicrorobotsmedical-roboticsdrug-deliverymagnetic-nanoparticlesinfertility-treatmentbiomedical-engineering3D-printed scaffolds guide stem cells to repair spinal cord injury
A research team at the University of Minnesota Twin Cities has developed a novel approach to spinal cord injury repair by combining 3D printing, stem cell biology, and regenerative medicine. They created a 3D-printed organoid scaffold containing microscopic channels filled with spinal neural progenitor cells (sNPCs) derived from human adult stem cells. These channels guide the growth of the stem cells, promoting the formation of new nerve fibers that can bypass damaged spinal cord areas. When implanted into rats with completely severed spinal cords, the scaffolds supported the development of neurons that extended nerve fibers in both directions, integrating with existing spinal tissue and leading to significant functional recovery. The study demonstrates that the scaffold not only enhances cell survival but also enables reconnection across severe spinal injuries, marking a promising advance in regenerative medicine for paralysis. The researchers plan to scale up and refine the technology for clinical trials, aiming to eventually restore mobility and independence in people with spinal cord injuries. This interdisciplinary project involved experts in neurosurgery
materials3D-printingregenerative-medicinestem-cellsspinal-cord-injurybiomedical-engineeringtissue-engineeringInjection-based drug delivery may replace cancer infusion drips
A Stanford research team has developed a novel drug delivery platform that could transform cancer and autoimmune disease treatments by replacing lengthy intravenous (IV) infusions with quick, high-concentration injections that patients can self-administer at home. The innovation centers on a specially designed polyacrylamide copolymer called MoNi, which stabilizes protein-based drugs at concentrations exceeding 500 mg/mL—more than double typical levels—without causing clumping or loss of efficacy. This is achieved by spray-drying protein molecules coated with MoNi into fine, glassy microparticles that remain stable under stress, including freeze-thaw cycles and high temperatures, and can be smoothly injected through tiny needles. The technology has been successfully tested on proteins such as albumin, human immunoglobulin, and a COVID antibody treatment, demonstrating broad applicability across biologic drugs. MoNi’s mechanical properties, rather than the chemical nature of the proteins, enable this versatility. Preclinical studies have shown no adverse effects, and the platform
materialsdrug-deliveryprotein-stabilitypolymer-sciencebiomedical-engineeringcancer-treatmentpharmaceutical-technologyUniversity of Waterloo researchers develop robots to directly treat kidney stones - The Robot Report
Researchers at the University of Waterloo, led by Dr. Veronika Magdanz, have developed a novel robotic technology aimed at directly treating kidney stones by dissolving them within the urinary tract. Kidney stones affect about 12% of people and often require prolonged drug treatments or surgeries, which can be painful and burdensome. The new minimally invasive approach uses thin, flexible, magnetically controlled strips about 1 cm long, embedded with the enzyme urease. These strips are maneuvered near uric acid kidney stones using a robotic arm guided by doctors, where the enzyme reduces urine acidity, accelerating stone dissolution so they can pass naturally within days. The technology was tested in life-size, 3D-printed urinary tract models and shows promise especially for patients who frequently develop stones or cannot tolerate oral medications or surgery due to risks like chronic infections. The system combines a motorized magnet on a robotic arm with real-time ultrasound imaging to precisely position the enzyme-loaded robots near the stones. Next steps for the
roboticsmedical-robotskidney-stone-treatmentrobotic-armminimally-invasive-surgerybiomedical-engineering3D-printingNew super-strong hydrogel can help advance biomedical and marine tech
Researchers at Hokkaido University have developed a new super-strong hydrogel with record-breaking underwater adhesive strength, capable of supporting objects weighing up to 139 pounds (63 kg) on a postage-stamp-sized patch. This hydrogel, inspired by adhesive proteins found in diverse organisms such as archaea, bacteria, viruses, and eukaryotes, was designed by analyzing nearly 25,000 natural adhesive proteins using data mining and machine learning techniques. By replicating key amino acid sequences responsible for underwater adhesion, the team synthesized 180 unique polymer networks, with machine learning further optimizing the hydrogel’s adhesive properties. The resulting material exhibits instant, strong, and repeatable adhesion across various surfaces and water conditions, including fresh and saltwater. The hydrogel’s adhesive strength was demonstrated through practical tests, such as holding a rubber duck firmly on a seaside rock despite ocean tides and waves, and instantly sealing a leaking pipe with a patch that could be reapplied multiple times without loss of effectiveness. Its
materialshydrogelunderwater-adhesionbiomedical-engineeringpolymer-networksmachine-learningbioinspired-materialsOrgan-on-a-chip tech is (almost) ready to replace animal models
Organ-on-a-chip (OoC) technology is emerging as a promising alternative to traditional animal models in drug testing and biomedical research. These microfluidic devices, engineered with human cells, replicate the structure and function of human organs on a miniature scale, allowing precise simulation of biological processes such as blood flow, cellular communication, and mechanical stresses. Unlike animal models, which often fail to accurately predict human responses—evidenced by nearly 90% of drug candidates failing in human trials despite success in animals—OoC systems offer more relevant human-specific insights. By incorporating cells from diverse donors, these chips can reflect variations in age, sex, and genetics, enabling personalized and predictive assessments of drug efficacy and disease mechanisms. The construction of organ-on-a-chip devices involves materials like polydimethylsiloxane (PDMS), thermoplastics, hydrogels, and glass, each chosen for specific properties such as flexibility, biocompatibility, and transparency. PDMS is currently favored due to
materialsmicrofluidicsorgan-on-a-chipbiomedical-engineeringdrug-testinghuman-cell-modelslab-on-a-chipMiniature chip mimics marrow to reshape blood cancer treatment
Researchers at NYU Tandon School of Engineering, led by Weiqiang Chen, have developed a credit-card-sized “leukemia-on-a-chip” device that replicates the bone marrow environment and a functioning human immune response. This miniature chip mimics the three key regions of bone marrow—blood vessels, marrow cavity, and bone lining—and supports patient-derived bone marrow cells to self-assemble and sustain immune activity. Using high-resolution imaging, the team observed immune cells, including engineered CAR T-cells, actively hunting and killing cancer cells in real time, providing unprecedented insights into immunotherapy dynamics and revealing phenomena like the “bystander effect,” where immune cells activate others beyond their direct targets. This chip-based platform addresses major limitations of current testing methods, such as slow, imprecise animal models and standard lab tests that fail to capture the complex cellular environment of cancer-immune interactions. It enables rapid, controlled experiments simulating clinical outcomes like remission, resistance, and relapse, and demonstrated that
materialsbiomedical-engineeringmicrochip-technologyimmunotherapycancer-treatmentlab-on-a-chipbiotechnologyDust-sized robots may soon clear sinus infections without antibiotics
Researchers from Guangxi University, Shenzhen University, and the Chinese University of Hong Kong have developed tiny, light-activated microrobots called CBMRs (copper single–atom–loaded bismuth oxoiodide photocatalytic microrobots) designed to treat bacterial sinus infections without antibiotics. These dust-sized robots can be injected into the sinus cavity via the nostrils and precisely guided by a magnetic field and a specially designed magnetically guided optical fiber. Once at the infection site, visible light activates the microrobots, enabling them to mechanically disrupt bacterial biofilms and generate antibacterial reactive oxygen species (ROS) that kill bacteria. This approach offers a noninvasive, drug-free alternative that minimizes antibiotic resistance and avoids the need for invasive surgery. Preclinical trials demonstrated the effectiveness of CBMRs in eliminating bacterial biofilms and clearing infections in animal models, including rabbits and pig sinuses, without causing tissue damage or side effects. The microrobots are naturally expelled
robotmicrorobotsmedical-roboticsantibacterial-technologysinus-infection-treatmentlight-activated-robotsbiomedical-engineeringNew 'claw machine' robot speeds up embryo model research
Researchers at the University of Washington and the Brotman Baty Institute have developed a novel automated robot, inspired by a "claw machine" design, to sort stem cell-derived embryo models called gastruloids. Gastruloids mimic the third week of human embryonic development, a critical phase when the body's three primary germ layers form. This new system enables scientists to efficiently isolate and study hundreds of gastruloids simultaneously, overcoming previous challenges of manual sorting that were time-consuming and prone to human error. The robot uses a combination of a microscope, digital camera, sliding stage, and microraft manipulation tools to precisely select individual gastruloids grown on tiny platforms. This automation not only speeds up research but also allows for more detailed investigation into the subtle variations between gastruloids, which can reveal insights into genetic drift, epigenetic influences, and developmental heterogeneity. Importantly, the technology facilitates studies on genetic disorders such as aneuploidy—abnormal chromosome numbers—by enabling analysis of how gastruloids with varying aneuploid cell proportions self-correct, shedding light on embryonic robustness. By providing a scalable, ethical, and precise platform for studying early human development, this innovation promises to accelerate advances in developmental biology, disease modeling, and regenerative medicine. The findings were published in APL Bioengineering.
roboticsautomationstem-cell-researchbiomedical-engineeringembryo-modelinglaboratory-roboticscell-sorting-technologyA Neuralink Rival Just Tested a Brain Implant in a Person
Paradromics, an Austin-based neurotechnology company founded in 2015, has conducted its first human test of Connexus, a brain implant designed to restore speech and communication in people with paralysis caused by spinal cord injury, stroke, or ALS. The device translates neural signals into synthesized speech, text, and cursor control by recording electrical activity from individual neurons via 420 tiny electrodes embedded in the brain tissue. The initial human implantation occurred on May 14 at the University of Michigan during epilepsy surgery, where the device was temporarily inserted into the temporal lobe using a specialized EpiPen-like tool. This procedure allowed researchers to confirm the device’s ability to capture neural signals with high resolution, which is critical for accurately decoding intended speech. Connexus is part of a growing field of brain-computer interface (BCI) technologies, including Elon Musk’s Neuralink and Synchron, which also develop implants to interpret neural signals but differ in electrode design and signal resolution. Unlike other devices that record from groups of neurons, Paradromics’ implant targets individual neurons to achieve higher-quality signals. BCIs do not read private thoughts but decode neural patterns associated with intended movements, such as facial muscle activity involved in speech. Recent studies from Stanford and UC San Francisco have demonstrated the ability to decode intended speech at rates approaching half of normal speaking speed in paralyzed individuals. Paradromics aims to launch a clinical trial by the end of 2023 to implant Connexus long-term in patients with paralysis, advancing toward commercial availability despite the regulatory and technical challenges of fully implantable brain devices.
robotbrain-computer-interfaceneural-implantsmedical-devicesneurotechnologyassistive-technologybiomedical-engineering